Celexa vs Zoloft I think I am. Lexapro is very similar to Celexa, it has one of the main components of Celexa, and tends to be overall easier to tolerate. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Schroeder on difference between citalopram and sertraline: Is equivalent to 20 mg of. Difference between Zoloft and Celexa. Depression is a normal part of life for many people, and for them, it is only the controlled and monitored use of antidepressant. Best Answer: They're quite similar. They're both SSRIs. Any individual's reaction to a drug is unpredictable. It's possible Celexa will work better for you. Which is better: Celexa or Zoloft? More patient posts reported that Zoloft helped them when used for Anxiety Yes, Celexa is good for anxiety. Friday when I had my appointment, my doctor asked me whether I'd like to try that (I was there to have my zoloft prescription. Lexapro vs Zoloft comparison. When it comes to prescription antidepressants, patients often try different drugs before settling on one that works best for them. 14 Answers - Posted in: buspar, celexa, zoloft, mirtazapine, antidepressant - Answer: I am not a Zoloft fan, it makes me feel like a different.